| Autor: |
Eguchi, Naomi, Pinzar, Elena, Kuwahata, Yuko, Inui, Takashi, Mochizuki, Takatoshi, Urade, Yoshihiro, Hayaishi, Osamu |
| Zdroj: |
International Congress Series; 2002, Vol. 1233 Issue: 0 p429-433, 5p |
| Abstrakt: |
Prostaglandin (PG) D 2 is a potent sleep-inducing substance in mammals. We investigated the effects of overproduction and deficiency of endogenous PGD 2 on sleep regulation by using transgenic (TG) mice overexpressing human lipocalin-type PGD synthase (L-PGDS) gene and gene-knockout (KO) mice produced by a null mutation of the L-PGDS gene, respectively. The circadian rhythm of non-rapid eye movement (NREM) and REM sleep was almost unchanged among wild-type (WT), TG, and KO mice. However, we found that noxious stimulation by tail clipping (Tc) of TG, but not of WT, mice transiently (∼5 h) increased the amount of NREM sleep without affecting REM sleep. This increase was coupled with elevation of the PGD 2 content in the brain, suggesting that the overproduction of PGD 2 in the brain by Tc induced NREM sleep in TG mice. We also found that sleep deprivation (SD) for 6 h induced rebound of NREM sleep in WT, but not in KO, mice, and of REM sleep in both of these mice, suggesting that the L-PGDS gene is involved in the homeostasis of NREM sleep after SD. Therefore, PGD 2 endogenously produced by L-PGDS in the brain is considered to regulate NREM sleep after noxious stimulation or SD. |
| Databáze: |
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