| Autor: |
Marsik, Frederic J., Parisi, Joseph T. |
| Zdroj: |
Applied Microbiology; January 1973, Vol. 25 Issue: 1 p11-14, 4p |
| Abstrakt: |
Susceptibility to 11 antibiotics was determined for 63 cultures of Staphylococcus aureusand 63 cultures of Staphylococcus epidermidisobtained at random from the clinical laboratory. The incidence of resistance to nine of these antibiotics was greater for S. epidermidisthan for S. aureus. Studies of the minimal inhibitory concentration of these cultures to clindamycin showed that 61 cultures of S. aureuswere susceptible whereas only 46 cultures of S. epidermidiswere susceptible to this antibiotic. Although cultures of S. aureuswere more active in the production of seven virulence factors, some cultures of S. epidermidisproduced virulence factors. By successive cultivation in increasing concentrations of clindamycin, resistant variants were obtained for 10 cultures of S. aureusand 3 cultures of S. epidermidis. The presence of subinhibitory concentrations of clindamycin inhibited the production of some virulence factors by the resistant variants. In view of the greater resistance of S. epidermidisto antibiotics and its ability to produce virulence factors, its isolation in the clinical laboratory should not be regarded lightly. |
| Databáze: |
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