| Autor: |
Munden, J. E., Butterworth, D., Hanscomb, G., Verrall, M. S. |
| Zdroj: |
Applied Microbiology; May 1970, Vol. 19 Issue: 5 p718-720, 3p |
| Abstrakt: |
Production of chlorflavonin, a new antifungal antibiotic, by strains of Aspergillus candidusis described. Two wild strains of the fungus had distinctly different chlorflavonin-producing capabilities. One strain produced 25 μg of chlorflavonin per ml per 4 to 5 days in a pilot scale fermentor with stirring, using a medium containing corn steep liquor and glucose. Production of antibiotic was favored by high rates of agitation-aeration. Crude chlorflavonin was extracted from the whole brew with a hydrocarbon solvent and then purified by recrystallization from benzene and petroleum ether. The overall yield from fermentation brew to pure product was 50%. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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