| Autor: |
Stottmeier, K. D., Kubica, G. P., Woodley, C. L. |
| Zdroj: |
Applied Microbiology; June 1969, Vol. 17 Issue: 6 p861-865, 5p |
| Abstrakt: |
Minimal inhibitory concentrations of rifampin for different species of mycobacteria were determined in 7H-10 agar medium and Lowenstein-Jensen egg medium. When rifampin was incorporated into egg medium, approximately 90% of its activity was lost. The stability of rifampin was tested during storage at different temperatures and concentrations. When tested in agar medium, a combination of isoniazid (INH) and rifampin inhibited multiple drug-resistant strains of Mycobacterium intracellulare,but under simulated in vivo conditions the drugs did not eliminate these same organisms. Drug-resistant mutants of M. intracellularemultiplied during an 8-day period when exposed 10 hr daily to the INH-rifampin regimen. However, combinations of rifampin and INH reduced drug-resistant mycobacterial populations by 99%, an effect which could not be enhanced by the addition of either erythromycin, ethionamide, or cycloserine. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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