| Autor: |
Hamilton, P. B., Rosi, D., Peruzzotti, G. P., Nielson, E. D. |
| Zdroj: |
Applied Microbiology; February 1969, Vol. 17 Issue: 2 p237-241, 5p |
| Abstrakt: |
Penicillium adametziand seven other species convert nalidixic acid, 1,4-dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid, to 1,4-dihydro-1-ethyl-7-hydroxymethyl-4-oxo-1,8-naphthyridine-3-carboxylic acid. Forty-seven other species from six orders of fungi seem to achieve the same conversion as judged by chromatographic and spectral evidence. Under special conditions, P. adametzialso produces a second metabolite which was identified as the corresponding 7-carboxylic acid. The metabolic attack on the ring substituent is identical with the pathway previously established with humans. No evidence was obtained for metabolic attack on the naphthyridine nucleus itself. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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