16α-Hydroxy Steroids

Autor: Goodman, Joseph J., Smith, Leland L.
Zdroj: Applied Microbiology; September 1961, Vol. 9 Issue: 5 p372-375, 4p
Abstrakt: 9α-Fluorohydrocortisone is hydroxylated by Streptomyces roseochromogenesin the 16α-, the 2β-, and in both the 16α- and 2β- positions. 16α-Hydroxylation appears to be the more predominant and rapid pathway of transformation. The degree of 2β-hydroxylation is dependent upon the strain used and may be increased to the point of its being a major route or virtually eliminated by the proper selection of isolates.
Databáze: Supplemental Index