| Autor: |
Day, David Philip, Mora Vargas, Jorge Andrés, Burtoloso, Antonio Carlos Bender |
| Zdroj: |
The Journal of Organic Chemistry; September 2021, Vol. 86 Issue: 17 p12427-12435, 9p |
| Abstrakt: |
The work reported herein showcases a new route to access α-fluoro-α-triazol-1-yl ketones from sulfoxonium ylides via α-azido-α-fluoro ketone intermediates. In a one-pot, two-step sequence, the ketosulfoxonium reactant initially undergoes insertion of F+and N3–, followed by a subsequent CuAAC reaction with arylacetylenes to install a 1,4-triazolo moiety. The approach allows for modification to both the sulfoxonium ylide and arylacetylene reactants. Fifteen examples have been reported, with yields ranging between 22% and 75%. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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