| Autor: |
Rodrigues, M M, Mendonça-Previato, L, Charlab, R, Barcinski, M A |
| Zdroj: |
Infection and Immunity; December 1987, Vol. 55 Issue: 12 p3142-3148, 7p |
| Abstrakt: |
Immunization of BALB/c mice with gp10/20, a glycoconjugate purified from Leishmania mexicana subsp. amazonensis, induced a delayed-type hypersensitivity response to the antigen, and a significant increase was elicited in the size of the lesion induced by a subcutaneous infection with this parasite. The increase in the lesion size was observed when mice were immunized by the subcutaneous and the intraperitoneal routes. The subcutaneous immunization with gp10/20 was unable to reverse the prophylactic effect of an intravenous injection of irradiated promastigotes. An L3T4+ T-cell line specific for gp10/20 was able to transfer this lesion-enhancing effect and specific delayed-type hypersensitivity reactivity to normal syngeneic recipients. The same T-cell line was a good producer of a hematopoietic growth factor, granulocyte-macrophage colony-stimulating factor. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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