Virus-induced diabetes mellitus in ICR Swiss mice is age dependent

Autor: Giron, D J, Cohen, S J, Lyons, S P, Trombley, M L, Gould, C L
Zdroj: Infection and Immunity; August 1983, Vol. 41 Issue: 2 p834-836, 3p
Abstrakt: Adult male ICR Swiss mice develop diabetes mellitus when infected with the D variant of encephalomyocarditis virus. It was determined that the disease syndrome caused by the virus in this mouse strain is dependent upon the age of the animals. Mice younger than 7 weeks developed lethal encephalitis, whereas those past this age developed diabetes. The susceptibility of young mice to the diabetogenic effects of encephalomyocarditis virus was enhanced by testosterone.
Databáze: Supplemental Index