Herpes virus Reactivation after Initiation of Interferon-Free Antiviral Agents in HIV–HCV-Coinfected Subjects: A New Immune Restoration Disease?

Autor: Marocco, Raffaella, Lichtner, Miriam, Tieghi, Tiziana, Pozzetto, Irene, Mastroianni, Claudio M
Zdroj: Antiviral Therapy; November 2016, Vol. 21 Issue: 8 p739-742, 4p
Abstrakt: We report four HCV–HIV-coinfected patients who developed herpes zoster or muco-cutaneous herpes virus disease shortly after starting interferon-free antiviral treatment for HCV. We suggest that in our patients the prompt clearance of HCV following direct-acting antivirals leads to a paradoxical effect on the innate and adaptive immune system mediating the reactivation of herpetic infection.
Databáze: Supplemental Index