| Autor: |
Adams, Jessica L, Byrne, Dana, Pepe, Rosalie, Gray, Anastasia, Baxter, John D |
| Zdroj: |
Antiviral Therapy; February 2016, Vol. 21 Issue: 2 p175-180, 6p |
| Abstrakt: |
Very high baseline HIV-1 RNA viral loads require potent and robust antiretroviral regimens to achieve virological suppression. The coformulated single tablet regimen of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate (EVG/COBI/FTC/TDF) is recommended by the US Department of Health and Human Services for the treatment of HIV-1 in treatment-naive adults and adolescents regardless of baseline CD4+T-cell count and viral load. We report two cases of HIV-infected, treatment-naive patients, with baseline HIV-1 RNA viral loads >1,000,000 copies/ml who were initiated on the single tablet regimen EVG/COBI/FTC/TDF, but failed to attain viral load suppression and developed resistance to the components of EVG/ COBI/FTC/TDF. |
| Databáze: |
Supplemental Index |
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