The HLA system in the families of patients with juvenile diabetes mellitus.

Autor: Rubinstein, P, Suciu-Foca, N, Nicholson, J F, Fotino, M, Molinaro, A, Harisiadis, L, Hardy, M A, Reemtsma, K, Allen, F H
Zdroj: The Journal of Experimental Medicine; May 1976, Vol. 143 Issue: 5 p1277-1282, 6p
Abstrakt: The HLA and Bf genotypes were determined in 10 families with one or more children with JDM. A statistically significant association was found between HLA-D-identity and the chance to present JDM within a sibship. No such association was detectable with the SD antigens. A highly significant increase in the frequency of intra-HLA recombination was also found in these families.
Databáze: Supplemental Index