| Autor: |
Bevilacqua, M P, Pober, J S, Majeau, G R, Cotran, R S, Gimbrone, M A |
| Zdroj: |
The Journal of Experimental Medicine; August 1984, Vol. 160 Issue: 2 p618-623, 6p |
| Abstrakt: |
Human monocyte-derived interleukin 1 (IL-1) was found to be a potent inducer of procoagulant activity in cultured human vascular endothelium. IL-1-induced human umbilical vein endothelial cell procoagulant activity (HEC-PCA) was transiently expressed, manifest in intact cell monolayers, and required protein synthesis. Data obtained with coagulation factor-deficient plasma and a goat anti-human apoprotein III antiserum suggested that most, if not all, of IL-1-induced endothelial cell procoagulant activity is tissue factor-like. IL-1 induction of HEC-PCA may be important in the pathogenesis of intravascular coagulation in a variety of immunological and inflammatory conditions. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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