| Autor: |
Rollwagen, F M, Stutman, O |
| Zdroj: |
The Journal of Experimental Medicine; December 1979, Vol. 150 Issue: 6 p1359-1366, 8p |
| Abstrakt: |
Culture of murine lymphoid cells without added antigen results in the generation of cells which suppress a variety of in vitro immune responses, such as the mixed lymphocyte response (MLR) and the generation of alloreactive cytotoxic T cells (CTL). The ontogeny of this phenomenon was studied. Cells which suppressed the MLR after preculture were isolated from spleens and hematopoietic livers of fetal and young (less than 1 wk old) mice. On the other hand, the generation of alloreactive CTL could be suppressed only by precultured spleen cells taken from 1-w-old or older mice. The parallel between the development of the suppressor functions and the maturation of the responses they regulate, suggests a possible biological significance of the effect. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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