| Autor: |
Mesri, E A, Cesarman, E, Arvanitakis, L, Rafii, S, Moore, M A, Posnett, D N, Knowles, D M, Asch, A S |
| Zdroj: |
The Journal of Experimental Medicine; May 1996, Vol. 183 Issue: 5 p2385-2390, 6p |
| Abstrakt: |
Herpesviral DNA fragments isolated from AIDS-associated Kaposi's sarcoma (KS) tissue (KSHV-DNA) share homology with two lymphotropic oncogenic gamma-herpesviruses, Epstein-Barr virus and Herpesvirus saimiri, and are present in the lesions of more than 95% of HIV and non-HIV-associated forms of KS, AIDS-related body cavity-based lymphomas, and AIDS-related multicentric Castleman's disease. Here we show that BC-1, a KSHV-DNA-positive, body cavity-based lymphoma cell line, produces infective herpesviral particles carrying a linear 270-kb genome that specifically transmits KSHV-DNA to CD19+ B cells. Transmission of KSHV-DNA is dependent upon a biologically active, replicating virus, since it is blocked by UV irradiation and foscarnet, an inhibitor of viral DNA-polymerase. This study represents the first isolation and transmission of the human herpesvirus-8/KS-associated herpesvirus. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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