| Autor: |
Pfeifer, J D, McKenzie, D T, Swain, S L, Dutton, R W |
| Zdroj: |
The Journal of Experimental Medicine; November 1987, Vol. 166 Issue: 5 p1464-1470, 7p |
| Abstrakt: |
In this report, we demonstrate that IL-4 is sufficient to stimulate both the proliferation and differentiation of Lyt-2+, Ia- splenic CTL precursors stimulated with the mitogenic lectin Con A. The response to IL-4 and Con A was not dependent on a putative endogenous production of IL-2 within the cultures, as demonstrated by an absence of an inhibitory effect by an anti-IL-2-R blocking mAb. Our results indicate that IL-2 and IL-4 can support an equivalent proliferative response by lectin-stimulated Lyt-2+ T lymphocytes, while IL-4 is more efficacious in stimulating their differentiation into mature cytolytically active cells. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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