| Autor: |
Cheng, G Y, Minden, M D, Toyonaga, B, Mak, T W, McCulloch, E A |
| Zdroj: |
The Journal of Experimental Medicine; February 1986, Vol. 163 Issue: 2 p414-424, 11p |
| Abstrakt: |
The organization and expression of the beta chain of T cell antigen receptor gene (beta-TCR) and Ig H and L chain genes were analyzed by Southern blot technique in 24 patients with a diagnosis of acute myeloblastic leukemia (AML). Rearrangements of the beta-TCR genes were seen in DNA samples from 3 of the 24 patients. One of these three patients also showed rearrangement of the Ig H chain gene. RNA samples from all three patients expressed a beta-TCR gene transcript on dot blot analysis. However, on Northern blot analysis, one patient expressed an incomplete 1.0 kb transcript and no Ig H chain mRNA, despite a rearranged configuration. The karyotypes of two of these patients showed abnormalities involving chromosome 7. Rearrangements of T cell antigen receptor genes may occur in nonlymphoid malignancy, and is consistent with the concept of lineage infidelity in AML. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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