| Autor: |
Rivkin, A., Cho, Y. S., Gabarda, A. E., Yoshimura, F., Danishefsky, S. J. |
| Zdroj: |
Journal of Natural Products; February 2004, Vol. 67 Issue: 2 p139-143, 5p |
| Abstrakt: |
There is wide interest in the epothilones, which like the taxoids initiate cytotoxicity through microtubule stabilization. Briefly described is an application of a ring-closing metathesis reaction toward the synthesis of epothilones as carried out in our laboratory. This has led to the discovery of the (E)-9,10-dehydroepothilones as second-generation anticancer drug candidates. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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