| Autor: |
Sowder, J T, Chen, C L, Ager, L L, Chan, M M, Cooper, M D |
| Zdroj: |
The Journal of Experimental Medicine; February 1988, Vol. 167 Issue: 2 p315-322, 8p |
| Abstrakt: |
This report describes an avian TCR molecule, TCR1, whose molecular characteristics, signal-transducing property, and tissue distribution suggest that it is a homologue of the mammalian TCR-gamma/delta. TCR1+ cells are the first to be generated in the thymus during ontogeny, preceding other T3+ cells by approximately 3 d. Unlike their mammalian counterpart, TCR1+ cells constitute a relatively large subpopulation of peripheral T cells in mature chickens. These results suggest a phylogenetically important role for this receptor in T cell development and function. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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