| Autor: |
Ralph, P, Nakoinz, I, Rennick, D |
| Zdroj: |
The Journal of Experimental Medicine; February 1988, Vol. 167 Issue: 2 p712-717, 6p |
| Abstrakt: |
Pretreatment of murine peritoneal exudate macrophages with 1-5 U/ml rIFN-gamma or rIL-2, or higher concentrations of IFN-alpha or IFN-beta greatly stimulated ADCC to Rl lymphoma targets. The assay was direct counting of viable target cells after 9 and 24 h using an E/T ratio of 5:1. 2d of pretreatment was optimal for enhancing ADCC. rIL-4 was inactive and IL-4-depleted Con A-induced spleen lymphokine retained its ADCC-stimulating activity. Antibody to IFN-gamma blocked the ADCC-promoting effect of the lymphokine, suggesting a major role for this factor. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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