| Autor: |
Tamm, Igor, Nemes, Marjorie M., Osterhout, Suydam |
| Zdroj: |
The Journal of Experimental Medicine; March 1960, Vol. 111 Issue: 3 p339-349, 11p |
| Abstrakt: |
Adenosine, but not guanosine, was capable of blocking the inhibitory effect of 5,6-dichloro-1-ß-D-ribofuranosylbenzimidazole (DRB) on influenza virus multiplication in the chorioallantoic membrane in vitro. At virus inhibitory concentrations DRB caused marked inhibition in uptake of adenosine-8-C14 into RNA of uninfected host cells, but it had little effect on uptake of C14-L-alanine into host cell proteins or on cellular oxygen consumption. The activity of DRB in inhibiting multiplication of the DNA-containing adenovirus was similar to its inhibitory activity on multiplication of the RNA-containing influenza virus. These and earlier results are discussed from the point of view of the important role of RNA in the reproduction of DNA-containing viruses. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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