Discontinuation versus continuation of renin-angiotensin-system inhibitors in COVID-19 (ACEI-COVID): a prospective, parallel group, randomised, controlled, open-label trial

Autor: Bauer, Axel, Schreinlechner, Michael, Sappler, Nikolay, Dolejsi, Theresa, Tilg, Herbert, Aulinger, Benedikt A, Weiss, Günter, Bellmann-Weiler, Rosa, Adolf, Christian, Wolf, Dominik, Pirklbauer, Markus, Graziadei, Ivo, Gänzer, Hannes, von Bary, Christian, May, Andreas E, Wöll, Ewald, von Scheidt, Wolfgang, Rassaf, Tienush, Duerschmied, Daniel, Brenner, Christoph, Kääb, Stefan, Metzler, Bernhard, Joannidis, Michael, Kain, Hans-Ulrich, Kaiser, Norbert, Schwinger, Robert, Witzenbichler, Bernhard, Alber, Hannes, Straube, Florian, Hartmann, Niels, Achenbach, Stephan, von Bergwelt-Baildon, Michael, von Stülpnagel, Lukas, Schoenherr, Sebastian, Forer, Lukas, Embacher-Aichhorn, Sabine, Mansmann, Ulrich, Rizas, Konstantinos D, Massberg, Steffen, Bantkowiak, Marcin, Baur, Gabriele, Baylacher, Monika, Beaucamp, Marcel, Berger, Manuel, Besch, Lisa, Brunner, Stefan, Budweiser, Stephan, Bugger, Heiko, Coletti, Raffaele, Dorwarth, Uwe, Egresits, Jozsef, Eiffener, Elodie, Faul, Christian, Finkenstedt, Armin, Gatos, Konstantinos, Gauchel, Nadine, Gindele, Frank, Grander, Wilhelm, Gunschl, Markus, Hartig, Frank, Hecht, Moritz, Heer, Tobias, Heger, Lukas, Hentrich, Marcus, Horvath, Lena, Keta, Dritan, Kiechl, Stefan, Kirchmaier, Rudolf, Klein, Andreas, Klemm, Mathias, Kolesnik, Ewald, König, Andreas, Kossmann, Hans Christian, Kropacek, Jana, Lanser, Lukas, Lother, Achim, Löw, Anja, Mahabadi, Amir-Abbas, Malleier, Stefan, Mayer, Gert, Müller, Christoph, Müller-Wieland, Dirk, Nagel, Bernhard, Neuwirt, Hannes, Olivier, Christoph, Raunegger, Thomas, Reindl, Martin, Reinstadler, Sebastian, Riesinger, Lisa, Schäffner, Michael, Schier, Johannes, Schock, Julia, Schönherr, Peter, Schulz, Martina, Schütz, Thomas, Schwarz, Johannes, Siebermair, Johannes, Siry, Marcus, Spaur, Anna, Sturm, Wolfgang, Tessadri, Kristin, Theurl, Fabian, Theurl, Markus, Thommes, Liz, Tiller, Christina, Toifl, Michael, Totzeck, Matthias, von zur Mühlen, Hedda, Vonderlin, Nadine, Wakili, Reza, Wendtner, Clemens, Wenner, Felix, Wimmert-Roidl, Daniela, Zabernigg, August
Zdroj: The Lancet Respiratory Medicine; August 2021, Vol. 9 Issue: 8 p863-872, 10p
Abstrakt: SARS-CoV-2 entry in human cells depends on angiotensin-converting enzyme 2, which can be upregulated by inhibitors of the renin–angiotensin system (RAS). We aimed to test our hypothesis that discontinuation of chronic treatment with ACE-inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) mitigates the course o\f recent-onset COVID-19.
Databáze: Supplemental Index