| Autor: |
Song, Joo Y, Perry, Anamarija M., Herrera, Alex F., Chen, Lu, Skrabek, Pam, Nasr, Michel, Ottesen, Rebecca, Nikowitz, Janet, Bedell, Victoria, Murata-Collins, Joyce, Li, Yuping, McCarthy, Christine, Pillai, Raju, Wang, Jinhui, Wu, Xiwei, Zain, Jasmine M., Popplewell, Leslie L., Kwak, Larry W, Nademanee, Auayporn P., Niland, Joyce, Scott, David W., Gong, Qiang, Chan, Wing (John) C., Weisenburger, Dennis D. |
| Zdroj: |
Blood; November 2020, Vol. 136 Issue: 1, Number 1 Supplement 1 p25-26, 2p |
| Abstrakt: |
Background:In diffuse large B-cell lymphoma (DLBCL), the presence of MYCand BCL2and/or BCL6translocations, so-called double-hit lymphoma (DH), has been associated with an aggressive clinical course. Recently, it was reported that gene expression profiling (GEP) could also identify cases with the biological and clinical characteristics of DH lymphoma, including some without the requisite translocations (DHITsig-positive cases)1. The purpose of this study was to develop a molecular subtyping schema for germinal center B-cell type (GCB) DLBCL using genomic studies such as fluorescence in situhybridization (FISH) cytogenetic analysis, GEP, and mutation analysis to risk-stratify patients with GCB DLBCL. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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