Scope and Predictive Genetic/Phenotypic Signatures of Bicarbonate (NaHCO3) Responsiveness and β-Lactam Sensitization in Methicillin-Resistant Staphylococcus aureus

Autor: Ersoy, Selvi C., Otmishi, Mariam, Milan, Vanessa T., Li, Liang, Pak, Youngju, Mediavilla, Jose, Chen, Liang, Kreiswirth, Barry, Chambers, Henry F., Proctor, Richard A., Xiong, Yan Q., Fowler, Vance G., Bayer, Arnold S.
Zdroj: Antimicrobial Agents and Chemotherapy; March 2020, Vol. 64 Issue: 5
Abstrakt: Addition of sodium bicarbonate (NaHCO3) to standard antimicrobial susceptibility testing medium reveals certain methicillin-resistant Staphylococcus aureus(MRSA) strains to be highly susceptible to β-lactams. We investigated the prevalence of this phenotype (NaHCO3responsiveness) to two β-lactams among 58 clinical MRSA bloodstream isolates. Of note, ∼75% and ∼36% of isolates displayed the NaHCO3responsiveness phenotype to cefazolin (CFZ) and oxacillin (OXA), respectively.
Databáze: Supplemental Index