Human Tissue Distribution of Voriconazole

Autor: Weiler, Stefan, Fiegl, David, MacFarland, Róisín, Stienecke, Eva, Bellmann-Weiler, Rosa, Dunzendorfer, Stefan, Joannidis, Michael, Bellmann, Romuald
Zdroj: Antimicrobial Agents and Chemotherapy; November 2010, Vol. 55 Issue: 2 p925-928, 4p
Abstrakt: ABSTRACTVoriconazole concentrations were determined in autopsy samples of eight patients who had been treated for a median of 7 days (interquartile range [IQR], 5 days). Voriconazole penetrates well into various tissues, with median levels of 6.26 μg/g ((interquartile range [IQR], 7.87 μg/g) in the lung, 3.41 μg/g (IQR, 16.72 μg/g) in the brain, 6.89 μg/g (IQR, 24.16 μg/g) in the liver, 6.47 μg/g (IQR, 6.19 μg/g) in the kidneys, 5.60 μg/g (IQR, 11.49 μg/g) in the spleen, and 7.55 μg/g (IQR, 16.91 μg/g) in the myocardium.
Databáze: Supplemental Index