| Autor: |
Zhao, Xilin, Malik, Muhammad, Chan, Nymph, Drlica-Wagner, Alex, Wang, Jian-Ying, Li, Xinying, Drlica, Karl |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; January 2006, Vol. 50 Issue: 1 p362-364, 3p |
| Abstrakt: |
ABSTRACTInhibition of DNA replication in an Escherichia coli dnaB-22mutant failed to block quinolone-mediated lethality. Inhibition of protein synthesis by chloramphenicol inhibited nalidixic acid lethality and, to a lesser extent, ciprofloxacin lethality in both dnaB-22and wild-type cells. Thus, major features of quinolone-mediated lethality do not depend on ongoing replication. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
