| Autor: |
Deurenberg, Ruud H., Vink, Cornelis, Oudhuis, Guy J., Mooij, Jascha E., Driessen, Christel, Coppens, Guy, Craeghs, Jos, De Brauwer, Els, Lemmen, Sebastian, Wagenvoort, Hans, Friedrich, Alexander W., Scheres, Jacques, Stobberingh, Ellen E. |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; October 2005, Vol. 49 Issue: 10 p4263-4271, 9p |
| Abstrakt: |
ABSTRACTThe Euregio Meuse-Rhine (EMR) is formed by the border regions of Belgium, Germany, and The Netherlands. Cross-border health care requires infection control measures, in particular since the prevalence of methicillin-resistant Staphylococcus aureus(MRSA) differs among the three countries. To investigate the dissemination of MRSA in the EMR, 152 MRSA isolates were characterized by pulsed-field gel electrophoresis (PFGE), SCCmectyping, and multilocus sequence typing. PFGE revealed major clonal groups A, G, L, and Q, suggesting dissemination of MRSA in the EMR. Group A harbored mainly SCCmectype III and sequence types (STs) 239 and 241. The majority of the strains from group G harbored SCCmectype I and ST8 and ST247, whereas most strains from group L carried either SCCmectype IV or type I. Within group L, ST8 and ST228 were found, belonging to clonal complexes 8 and 5, respectively. Most strains from group Q included SCCmectype II and were sequence typed as ST225. Both ST225-MRSA-II and ST241-MRSA-III were novel findings in Germany. In addition, the SCCmectype of two isolates has not been described previously. One strain was classified as SCCmectype III but harbored the plsgene and the dcsregion. Another strain was characterized as SCCmectype IV but lacked the dcsregion. In addition, one isolate harbored both SCCmectype V and Panton-Valentine leukocidin. Finally, the SCCmectype of the strains was found to be correlated with the antibiotic susceptibility pattern. |
| Databáze: |
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