| Autor: |
Harmoinen, Jaana, Mentula, Silja, Heikkilä, Matti, van der Rest, Michel, Rajala-Schultz, Päivi J., Donskey, Curtis J., Frias, Rafael, Koski, Pertti, Wickstrand, Nina, Jousimies-Somer, Hannele, Westermarck, Elias, Lindevall, Kai |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; January 2004, Vol. 48 Issue: 1 p75-79, 5p |
| Abstrakt: |
ABSTRACTAntibiotics that are excreted into the intestinal tract promote antibiotic resistance by exerting selective pressure on the gut microbiota. Using a beagle dog model, we show that an orally administered targeted recombinant β-lactamase enzyme eliminates the portion of parenteral ampicillin that is excreted into the small intestine, preventing ampicillin-induced changes to the fecal microbiota without affecting ampicillin levels in serum. In dogs receiving ampicillin, significant disruption of the fecal microbiota and the emergence of ampicillin-resistant Escherichia coliand TEM genes were observed, whereas in dogs treated with ampicillin in combination with an oral β-lactamase, these did not occur. These results suggest a new strategy for reducing antimicrobial resistance in humans. |
| Databáze: |
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