In Vitro Activities of ABT-492, a New Fluoroquinolone, against 155 Aerobic and 171 Anaerobic Pathogens Isolated from Antral Sinus Puncture Specimens from Patients with Sinusitis

Autor: Goldstein, Ellie J. C., Citron, Diane M., Merriam, C. Vreni, Warren, Yumi A., Tyrrell, Kerin L., Fernandez, Helen T.
Zdroj: Antimicrobial Agents and Chemotherapy; September 2003, Vol. 47 Issue: 9 p3008-3011, 4p
Abstrakt: ABSTRACTABT-492 exhibited excellent in vitro activities against all 326 aerobic and anaerobic antral puncture sinus isolates tested with MICs (in micrograms per milliliter) at which 90% of the isolates tested were inhibited as follows: Haemophilus influenzae, 0.001; Moraxella catarrhalis, 0.008; and Streptococcus pneumoniae, 0.015. It was four- to sixfold more active than other fluoroquinolones, including against levofloxacin-resistant strains of S. pneumoniae, methicillin-resistant Staphylococcus aureus, and Prevotellaspecies.
Databáze: Supplemental Index