| Autor: |
Dailey, Charlene F., Pagano, Paul J., Buchanan, Lewis V., Paquette, Jennifer A., Haas, Joseph V., Gibson, John K. |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; August 2003, Vol. 47 Issue: 8 p2655-2658, 4p |
| Abstrakt: |
ABSTRACTThe efficacy of linezolid, alone or in combination with rifampin, against methicillin-susceptible Staphylococcus aureusin rabbits with experimental endocarditis was investigated. Linezolid (50 or 75 mg/kg of body weight), rifampin, and linezolid (25, 50, or 75 mg/kg) plus rifampin produced statistically significant reductions in bacterial counts compared with those in untreated controls. Plasma or valvular vegetation levels of linezolid in the groups treated with the linezolid-rifampin combination were similar to those in the respective linezolid-only treatment groups. At therapeutic levels of linezolid, rifampin resistance was not observed. The results from this experimental model of endocarditis suggest that while rifampin did not provide synergy to the linezolid dosing, it did not antagonize the efficacy of linezolid. |
| Databáze: |
Supplemental Index |
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