| Autor: |
Martin, M., Serradji, N., Dereuddre-Bosquet, N., Le Pavec, G., Fichet, G., Lamouri, A., Heymans, F., Godfroid, J. J., Clayette, P., Dormont, D. |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; November 2000, Vol. 44 Issue: 11 p3150-3154, 5p |
| Abstrakt: |
ABSTRACTWe assessed the anti-human immunodeficiency virus (anti-HIV) activity in vitro of new platelet-activating factor (PAF) receptor antagonists, as PAF and viral replication are thought to be involved in HIV neuropathogenesis. We found that PMS-601 inhibited proinflammatory cytokine synthesis and HIV replication in macrophages and potentiated the antiretroviral activity of zidovudine. These results suggest that PMS-601 is of potential value as an adjuvant treatment for HIV infection. |
| Databáze: |
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