| Abstrakt: |
ABSTRACTThe activities of gemifloxacin (SB 265805, LB20304) and comparator agents were determined by an agar dilution method against 419 clinical strains of less-commonly identified species of anaerobes. Gemifloxacin was generally more active than trovafloxacin against gram-positive strains by one to two dilutions. Peptostreptococci (Peptostreptococcus asaccharolyticus,Peptostreptococcus magnus, Peptostreptococcus micros, and Peptostreptococcus prevotii) andPorphyromonasspp. (Porphyromonas asaccharolytica, Porphyromonas canoris,Porphyromonas gingivalis, and Porphyromonas macacae) were all susceptible to ≤0.25 μg of gemifloxacin per ml. The MICs of gemifloxacin at which 90% of the following strains were inhibited (MIC90s) were ≤2 μg/ml: Actinomyces israelii, Actinomyces odontolyticus,Clostridium innocuum, Clostridium clostridioforme, Anaerobiospirillumspp.,Bacteroides tectum, Bacteroides ureolyticus,Bacteroides gracilis(now Campylobacter gracilis), Prevotella intermedia, Prevotella heparinolytica, and the Prevotella oris-buccaegroup.Fusobacterium naviformeand Fusobacterium necrophorumwere also susceptible to ≤2 μg of gemifloxacin per ml, while Fusobacterium variumstrains exhibited a bimodal pattern; the other Fusobacteriumspecies, such asFusobacterium ulceransand Fusobacterium russii, as well as Veillonellaspp., thePrevotella melaninogenicagroup, Prevotella bivia, Clostridium difficile, and Bilophila wadsworthiawere relatively resistant to gemifloxacin (MIC90s, ≥4 μg/ml). |
