| Autor: |
Winter, R W, Cornell, K A, Johnson, L L, Ignatushchenko, M, Hinrichs, D J, Riscoe, M K |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; June 1996, Vol. 40 Issue: 6 p1408-1411, 4p |
| Abstrakt: |
We have discovered a remarkable synergistic antimalarial interaction between rufigallol and the structurally similar compound exifone. The synergistic effects were produced in chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. The degree of potentiation as estimated by standard isobolar analysis was approximately 60-fold for experiments initiated with asynchronous parasites. The most pronounced synergism was observed in experiments with synchronized trophozoite-infected erythrocytes, in which the degree of synergy was at least 300-fold. While the mechanism underlying this drug potentiation remains unresolved, it is hypothesized that rufigallol acts in pro-oxidant fashion to produce oxygen radicals inside parasitized erythrocytes. These radicals would attack exifone, thereby initiating its transformation into a more potent compound, a xanthone. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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