| Autor: |
Shakiba, S, Freeman, W R, Flores-Aguilar, M, Munguia, D, Tatebayashi, M, Besen, G, Amani, R, Wiley, C A, Vuong, C, Aldern, K A |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; June 1995, Vol. 39 Issue: 6 p1383-1385, 3p |
| Abstrakt: |
Acyclovir diphosphate dimyristoylglycerol (ACVDP-DG) is a lipid prodrug which is active against ACV-resistant strains of herpes simplex virus because of its intracellular metabolism to ACV monophosphate. In human cytomegalovirus (HCMV)-infected MRC-5 cells, ACVDP-DG was ninefold more active than ACV. When liposomal [8-3H]ACVDP-DG was injected intravitreally at the maximum nontoxic dose of 1 mumol in rabbits, the drug remained above its estimated 90% HCMV-inhibitory concentration for 18 days. Intravitreal ganciclovir persists above its 90% inhibitory concentration for only 1 to 2 days. ACVDP-DG may be useful as a local treatment for HCMV retinitis. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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