Ile) and 181 (Tyr-->Cys), which mediate resistance to the nonnucleosides, suppressed resistance to 3'-azido-3'-deoxythymidine (AZT) when coexpressed with AZT-specific substitutions. However, a number of viral variants that exhibited significantly reduced susceptibilities to both classes of inhibitors were constructed.
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| Autor: |
Byrnes, V W, Emini, E A, Schleif, W A, Condra, J H, Schneider, C L, Long, W J, Wolfgang, J A, Graham, D J, Gotlib, L, Schlabach, A J |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; June 1994, Vol. 38 Issue: 6 p1404-1407, 4p |
| Abstrakt: |
To evaluate the potential that multiply resistant human immunodeficiency virus type 1 variants may arise during combination nucleoside and nonnucleoside reverse transcriptase inhibitor therapy, we constructed a series of mutant reverse transcriptase enzymes and viruses that coexpressed various combinations of resistance-associated amino acid substitutions. Substitutions at residues 100 (Leu-->Ile) and 181 (Tyr-->Cys), which mediate resistance to the nonnucleosides, suppressed resistance to 3'-azido-3'-deoxythymidine (AZT) when coexpressed with AZT-specific substitutions. However, a number of viral variants that exhibited significantly reduced susceptibilities to both classes of inhibitors were constructed. |
| Databáze: |
Supplemental Index |
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