| Autor: |
Condreay, L D, Jansen, R W, Powdrill, T F, Johnson, L C, Selleseth, D W, Paff, M T, Daluge, S M, Painter, G R, Furman, P A, Ellis, M N |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; March 1994, Vol. 38 Issue: 3 p616-619, 4p |
| Abstrakt: |
A murine model was developed to investigate the in vivo activity of anti-hepatitis B virus (HBV) agents. Mice with subcutaneous tumors of HBV-producing 2.2.15 cells showed reductions in levels of HBV in serum and in intracellular levels of HBV when the mice were orally dosed with (-) cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine (FTC). No effects on tumor size or alpha-fetoprotein levels were observed. FTC can selectively inhibit HBV replication at nontoxic doses. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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