Identification of TEM-26 beta-lactamase responsible for a major outbreak of ceftazidime-resistant Klebsiella pneumoniae

Autor: Urban, C, Meyer, K S, Mariano, N, Rahal, J J, Flamm, R, Rasmussen, B A, Bush, K
Zdroj: Antimicrobial Agents and Chemotherapy; February 1994, Vol. 38 Issue: 2 p392-395, 4p
Abstrakt: An epidemic of nosocomial ceftazidime-resistant Klebsiella pneumoniae was correlated with production of a ceftazidime-hydrolyzing enzyme with an isoelectric point of 5.6 (BMH-1). BMH-1 was encoded on a large transferable plasmid conferring multiple antibiotic resistance. The gene that encodes BMH-1 was identical to the gene that encodes the TEM-26 extended-spectrum beta-lactamase.
Databáze: Supplemental Index