| Autor: |
Reinhard, M K, Bekersky, I, Sanders, T W, Harris, B J, Hottendorf, G H |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; January 1994, Vol. 38 Issue: 1 p79-82, 4p |
| Abstrakt: |
To provide insight into polyaspartic acid nephroprotection and differences in aminoglycoside renal toxicity between two rat strains, the single-dose pharmacokinetics of tobramycin was examined in the presence and absence of polyaspartic acid. Following a single subcutaneous 6.5-mg/kg dose of tobramycin alone, higher aminoglycoside concentrations were measured in Sprague-Dawley rats than in Fischer rats (P < 0.05). Simultaneous administration of polyaspartic acid (50 mg/kg) and tobramycin did not alter the concentrations of tobramycin in serum. The amount of tobramycin in renal tissue and the amount recovered in urine over a 24-h period were greater in both rat strains when tobramycin and polyaspartic acid were given concomitantly. In summary, polyaspartic acid did not alter the concentrations in serum achieved after a single dose of tobramycin in two different rat strains but did result in higher renal concentrations and greater urinary excretion of tobramycin. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
