| Autor: |
Nightingale, S D, Saletan, S L, Swenson, C E, Lawrence, A J, Watson, D A, Pilkiewicz, F G, Silverman, E G, Cal, S X |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; September 1993, Vol. 37 Issue: 9 p1869-1872, 4p |
| Abstrakt: |
TLC G-65, a liposome-encapsulated gentamicin, was given intravenously twice weekly for 4 weeks to AIDS patients with Mycobacterium avium-M. intracellulare complex (MAC) bacteremia at 1.7 mg of gentamicin per kg of body weight per infusion (4 patients), 3.4 mg/kg (10 patients), and 5.1 mg/kg (7 patients). MAC colony counts in blood fell by 75% or more in all three groups (P < 0.005). Drug resistance did not emerge during the study period. Transient renal insufficiency developed in one patient; no other adverse effects were detected. Liposome-encapsulated gentamicin is a potential therapy for MAC infections in AIDS patients. |
| Databáze: |
Supplemental Index |
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