| Autor: |
Merle-Melet, M, Bresler, L, Lokiec, F, Dopff, C, Boissel, P, Dureux, J B |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; October 1992, Vol. 36 Issue: 10 p2331-2333, 3p |
| Abstrakt: |
The effects of diclofenac, a nonsteroidal antiinflammatory drug, on the biliary and urinary excretion of ceftriaxone were evaluated in subjects with a T drain in the common bile duct. The kinetic study was carried out on the sixth postoperative day of treatment with ceftriaxone alone (2 g intravenously; group 1) or ceftriaxone combined with diclofenac (50 mg every 12 h orally from postoperative days 3 to 6; group 2). A significant increase in the elimination half-life of ceftriaxone was observed in group 2 patients. Diclofenac caused a significant rise in ceftriaxone biliary excretion. This increase was not sufficient to balance the significant deficit of urinary excretion of ceftriaxone. |
| Databáze: |
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| Externí odkaz: |
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