| Autor: |
Grayson, M L, Thauvin-Eliopoulos, C, Eliopoulos, G M, Yao, J D, DeAngelis, D V, Walton, L, Woolley, J L, Moellering, R C |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; September 1990, Vol. 34 Issue: 9 p1792-1794, 3p |
| Abstrakt: |
To assess the potential efficacy of trimethoprim-sulfamethoxazole (TMP-SMX) against serious enterococcal infections, we used a rat enterococcal endocarditis model comparing TMP-SMX therapy (500 mg of TMP plus 2,500 mg of SMX per kg of body weight per day given every 8 h by intragastric gavage) with intravenous ampicillin therapy (1,000 mg/kg per day). Despite concentrations of active drug in serum well in excess of the MIC and MBC, the mean residual vegetation bacterial titer in TMP-SMX-treated rats was similar to that in untreated controls (8.4 +/- 1.1 versus 8.6 +/- 1.3 log10 CFU/g) and significantly higher than that in the ampicillin-treated group (3.6 +/- 1.5 log10 CFU/g; P less than or equal to 0.001). This demonstrates discordance between in vitro activity and in vivo efficacy of TMP-SMX in serious enterococcal infection. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
