| Autor: |
Nsiah, Y A, Tolman, R L, Karkas, J D, Rapp, F |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; August 1990, Vol. 34 Issue: 8 p1551-1555, 5p |
| Abstrakt: |
Latent herpes simplex virus type 1 (HSV-1) infection was induced in human embryonic lung cells in vitro by using a combination of viral replication inhibitors and elevated temperature. Under reactivating conditions (superinfection by human cytomegalovirus or temperature manipulation), a nonantiviral thymidine kinase inhibitor (L-653,180) was found to suppress or delay reactivation of HSV-1 from latently infected human embryonic lung cells. L-653,180 alone or in combination with interferon was ineffective as a primary or acute viral replication inhibitor and was unable to induce latent HSV-1 infection in cell culture. These data suggest that initial or acute virus replication and replication resulting from reactivation from latency are separate events. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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