| Autor: |
Foweraker, J E, Hawkey, P M, Heritage, J, Van Landuyt, H W |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; August 1990, Vol. 34 Issue: 8 p1501-1504, 4p |
| Abstrakt: |
A novel beta-lactamase activity which confers resistance to expanded-spectrum cephalosporins and penicillins has been found in strain IC 5/21 of Capnocytophaga spp. Enzyme activity migrated at a molecular size of 38,000 daltons and at an isoelectric point of 3.6, with a minor band at 4.1. Kinetic studies suggested that it belonged to Richmond and Sykes beta-lactamase class 1c. Isoelectric focusing could be achieved only if a nonionic detergent was added to the gel, suggesting the presence of a hydrophobic enzyme akin to a membrane-bound beta-lactamase of gram-positive bacteria. The location of the gene coding for this beta-lactamase is not yet known. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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