| Autor: |
Sintnicolaas, K., Kooij, M. van Marwijk, Prooijen, H.C. van, Dijk, B.A. van, Putten, W.L.J. van, Claas, F.H.J., Novotny, V.M.J., Brand, A. |
| Zdroj: |
Blood; February 1995, Vol. 85 Issue: 3 p824-828, 5p |
| Abstrakt: |
We studied the value of leukocyte depletion of platelet transfusions for the prevention of secondary human leukocyte antigen (HLA)-alloimmunization in patients with a high-risk of prior immunization induced by pregnancies. Seventy-five female patients with hematologic malignancies (mostly acute leukemia) and a history of pregnancy were randomized to receive either standard random single-donor platelet transfusions (mean leukocytes, 430 × 106per transfusion) or leukocyte-depleted random single-donor platelet transfusions, Leukocyte depletion to less than 5 × 106leukocytes per platelet transfusion (mean leukocytes, 2 × 106per transfusion) was achieved by filtration. Of the 62 evaluable patients, refractoriness to random donor platelets occurred in 41% (14 of 34) of the patients in the standard group and in 29% (8 of 28) of the patients in the filtered group (P= .52); anti-HLA antibodies developed in 43% (9 of 21) of individuals in the standard group and 44% (11 of 25) of cases in the filtered group. The time toward refractoriness and development of anti-HLA antibodies was similar for both groups. We conclude that leukocyte depletion of random single-donor platelet products to less than 5 × 106per transfusion does not reduce the incidence of refractoriness to random donor platelet transfusions because of boostering of anti-HLA antibodies. |
| Databáze: |
Supplemental Index |
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