| Autor: |
Payne, Claire M., Jones, James F., Sieber, Otto F., Fulginiti, Vincent A. |
| Zdroj: |
Blood; July 1977, Vol. 50 Issue: 1 p55-64, 10p |
| Abstrakt: |
The ultrastructure of the lymphocytes from three children with severe combined immunodeficiency disease (SCID) is described. Parallel tubular arrays (PTA) were found in a large percentage of circulating lymphocytes (53%, 41%, and 13%) in three SCID patients when compared to age-matched controls. The size of these inclusions was quite variable, with some attaining a length of 1.7 μm. They contained a tubular substructure with a diameter of 36-44 nm. The PTA were mostly located in the centriolar and Golgi regions of the cytoplasm, and were sometimes membrane bound. A centriolar origin of the inclusion was suggested. A second inclusion, the tubuloreticular structure, was found in only 1.4% of the circulating lymphocytes from one SCID patient. The origin of the PTA and its occurrence in severe combined immunodeficiency disease are discussed. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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