| Autor: |
Anderson, Kenneth C., Bates, Michael P., Slaughenhoupt, Bruce L., Pinkus, Geraldine S., Schlossman, Stuart F., Nadler, Lee M. |
| Zdroj: |
Blood; June 1984, Vol. 63 Issue: 6 p1424-1433, 10p |
| Abstrakt: |
A series of monoclonal antibodies that define B cell restricted and associated antigens was utilized in an attempt to characterize tumors of B lineage and to relate these tumors to B cell differentiative stages. Antigens that were previously shown to be B cell restricted on normal B lymphocytes were similarly expressed only on B cell malignancies. In contrast, antigens that were B cell associated were also found on tumors of other lineages. Moreover, on the basis of cell surface phenotypes, tumors of B cell origin were divided into three major subgroups, which corresponded to the level of differentiation of the malignant tumor cell: pre-B cell stage (non-T acute lymphoblastic leukemia and chronic myelocytic leukemia in lymphoid blast crisis); the mid-B cell stage (chronic lymphocytic leukemia, poorly differentiated lymphomas); and secretory B cell stage (large cell lymphomas and plasma cell tumors). A hypothetical model is derived that relates the malignant B cell to its normal cellular counterpart on the basis of cell surface expression of this panel of B cell-restricted and B cell-associated antigens. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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