| Autor: |
Fletcher, C V, Englund, J A, Bean, B, Chinnock, B, Brundage, D M, Balfour, H H |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; August 1989, Vol. 33 Issue: 8 p1375-1378, 4p |
| Abstrakt: |
Thirteen patients with herpesvirus infections who were unresponsive to at least 72 h of intermittent acyclovir administration received high-dose continuous infusion. Steady-state concentrations were maintained at between 20 and 98 mumol/liter. Of 12 patients who had continuous infusion for greater than 5 days, 7 (58%) resolved their infections, as determined by clinical and virologic parameters, suggesting that continuous infusion may succeed in some patients who do not respond to conventional therapy. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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