| Autor: |
Gangadharam, P R, Kesavalu, L, Rao, P N, Perumal, V K, Iseman, M D |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; June 1988, Vol. 32 Issue: 6 p886-889, 4p |
| Abstrakt: |
We studied the activity of amikacin against Mycobacterium avium complex strain 101 by using continuous-level, changing concentrations which simulated levels in serum in a patient, and pulsed exposures. Amikacin at a concentration of 5 or 15 micrograms/ml showed rapid bactericidal action following constant exposure of the organisms. With the in vitro model, using a peak concentration of 10 or 20 micrograms/ml, complete sterilization was obtained by day 7. In pulsed-exposure studies, a minimum period of contact of 72 or 96 h at a concentration of 10 micrograms/ml was needed for complete sterilization. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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