| Autor: |
Shoeb, H A, Bowman, B U, Ottolenghi, A C, Merola, A J |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; March 1985, Vol. 27 Issue: 3 p404-407, 4p |
| Abstrakt: |
Crude extracts of Mycobacterium tuberculosis H37Ra, an isonicotinic acid hydrazide (isoniazid) (INH)-susceptible strain which has peroxidase activity, catalyzed the production of catechol from phenol in the presence of INH and H2O2 as shown by the development of the 444-nm absorption peak of oxidized catechol product. Extracts of the INH-resistant strain of M. tuberculosis H37Ra, which has no peroxidase, did not catalyze the reaction. The rate of development of the 444-nm peak increased proportionately with increased superoxide dismutase concentrations. The hydroxyl radical (. OH) scavengers dimethylsulfoxide and mannitol inhibited the reaction. Isonicotinamide, isonicotinic acid, and nicotinic acid could not replace INH. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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