| Autor: |
Daum, R S, Glode, M P, Ambrosino, D, Halsey, N, Goldmann, D A, Mather, F J, Russell, R, Kamon, J, Murray, M, Band, J D |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; November 1983, Vol. 24 Issue: 5 p658-662, 5p |
| Abstrakt: |
We compared the effectiveness of rifampin-trimethoprim in fixed combination (3.75:1) to rifampin alone in the eradication of Haemophilus influenzae type b carriage among contacts of patients with invasive infection caused by this organism. The study population was composed of 127 index patients and 620 contacts. Twenty-six percent of contacts were colonized. Rifampin-trimethoprim eradicated carriage in 77.6% of contacts (71.1% in contacts less than 5 years, 84.2% in contacts greater than or equal to 5 years) whereas rifampin eradicated carriage in 69.9% of contacts (56.4% in contacts less than 5 years, 81.8% in contacts greater than or equal to 5 years). A single isolate resistant to rifampin and rifampin-trimethoprim was encountered. The eradication rate achieved with this regimen of rifampin-trimethoprim was too low to recommend its routine use. However, a higher dose or longer course might merit clinical trial. |
| Databáze: |
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